Endocrine Abstracts

Both type 1 and type 2 diabetes are associated with accelerated atherosclerosis. Multiple mechanisms contribute to the atherosclerotic process; however, inflammation and oxidative stress are underlying common factors. In genetically-prone atherosclerotic mouse models, inhibition of macrophage inflammatory capacity and oxidative stress substantially attenuate atherosclerosis extent and complexity. These approaches also attenuate the adipocyte response to high fat diet and adoip...

The availability of genome sequences from humans and multiple model organisms has facilitated the identification of many human plasma membrane receptor families and allowed the analysis of their phylogeny. We traced the evolution of known families of human plasma membrane receptors for inclusion in the Human Plasma Membrane Receptome database at http://receptome.stanford.edu (Science STKE. 2003). Using an evolutionary approach, we identified new polypeptide hormones and recept...